Why Nitrosigine?

By September 29, 2015July 11th, 2021No Comments

By Michael Colgan, Ph.D.

When I first suggested how to increase the anabolic drive of the human body in Optimum Sports Nutrition in 1993, I recommended use of the amino acid arginine (1).  I covered the forms, arginine hydrochloride and the better absorbed arginine alpha-ketoglutarate, the carbon skeleton of arginine. I also covered the conditions under which to take them to increase release of growth hormone, and to increase blood flow to muscles.

Even in the alpha-ketoglutarate form, arginine is difficult to get into the brain, because it is always in competition with the essential amino acid lysine for a very limited transport mechanism across the blood-brain barrier. But that was as good as sports science could get until now. Then the FDA approved sale of arginine bonded to silicate as a nutritional supplement in 2014.

They have called the supplement, Nitrosigine in the marketplace, because of laboratory evidence that it boosts levels of nitric oxide (2). Clinical research gave healthy male volunteers aged 18 to 40 a dose of 1,500 mg Nitrosigine per day for 14 days.

Nitrosigine has the same effects as previous forms of arginine – but better. Read Chapter 30 of my book to find out more (1). It is cleverly engineered with silica and inositol to take effect in just 30 minutes, producing increased blood levels of arginine that can last through a two hour workout.

Results showed that kallistatin, a potent vasodilator, increased by 32 percent, and almost doubled blood flow.  Increased blood flow is performance gold to athletes. It means increased oxygen and nutrient supplies to the muscles that can boost both aerobic and anaerobic performance.

About Dr. Colgan

Michael-Colgan-107x135Dr. Michael Colgan is a world-renowned research scientist, leading expert in the inhibition of aging, and a member of the Isagenix Science Advisory Board. Dr. Colgan has provided nutrition, training and anti-aging programs to more than 11,000 athletes, including many Olympians. He is director of his eponymous Colgan Institute, a consulting, educational and research facility concerned with the effects of nutrition and exercise on athletic performance, along with prevention of chronic degenerative disease, and prevention of degeneration of the brain. Dr Colgan’s sports articles are published on his blog


  1. Colgan M. Optimum Sports Nutrition. New York: Advanced Research Press, 1993.
  2. Kalman D, et al. A clinical evaluation to determine the safety, pharmacokinetics and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. (LB418) FASEB Journal, 2014;28(1):SLB418.

Source: Isogenix



About Koko